Manidipine
Modify Date: 2024-01-02 12:56:50
Manidipine structure
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Common Name | Manidipine | ||
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| CAS Number | 89226-50-6 | Molecular Weight | 610.699 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 722.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C35H38N4O6 | Melting Point | 125-128ºC | |
| MSDS | N/A | Flash Point | 390.4±32.9 °C | |
Use of ManidipineManidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3]. |
| Name | 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
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| Synonym | More Synonyms |
| Description | Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 722.0±60.0 °C at 760 mmHg |
| Melting Point | 125-128ºC |
| Molecular Formula | C35H38N4O6 |
| Molecular Weight | 610.699 |
| Flash Point | 390.4±32.9 °C |
| Exact Mass | 610.279114 |
| PSA | 116.93000 |
| LogP | 5.46 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.601 |
| Storage condition | -20°C Freezer |
| Hazard Codes | Xi |
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Manidipine CAS#:89226-50-6 |
| Literature: WO2011/23954 A2, ; Page/Page column 18 ; |
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~77%
Manidipine CAS#:89226-50-6 |
| Literature: Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797 |
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~%
Manidipine CAS#:89226-50-6 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797 |
|
~%
Manidipine CAS#:89226-50-6 |
| Literature: WO2011/23954 A2, ; |
|
~%
Manidipine CAS#:89226-50-6 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797 |
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~%
Manidipine CAS#:89226-50-6 |
| Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797 |
CAS#:89226-75-5| 2-[4-(Diphenylmethyl)-1-piperazinyl]ethylmethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate |
| 2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE |
| 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester |
| 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine |
| 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate |
| 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Manidipine 6300 |
| Manidipine |
| UNII:6O4754US88 |
| CV-4093,2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate |
| Manidipine (Manyper) |
| 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| (+/-)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester |
| 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate |
| 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Franidipine |
| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Manidipine
- Price: ￥338.0/50mg ￥1008.0/250mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Manidipine(CV-4093)
- Price: $250.0/100mg $500.0/250mg $1000.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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Price: $180/100mg
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