Manidipine

Modify Date: 2025-08-21 20:39:31

Manidipine structure	Common Name	Manidipine
	CAS Number	89226-50-6	Molecular Weight	610.699
	Density	1.2±0.1 g/cm3	Boiling Point	722.0±60.0 °C at 760 mmHg
	Molecular Formula	C₃₅H₃₈N₄O₆	Melting Point	125-128ºC
	MSDS	N/A	Flash Point	390.4±32.9 °C

Use of Manidipine

Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3].

Name	3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonym	More Synonyms

Description	Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
References	[1]. Cheer, S.M. and K. McClellan, Manidipine: a review of its use in hypertension. Drugs, 2001. 61(12): p. 1777-99. [2]. McKeage, K. and L.J. Scott, Manidipine: a review of its use in the management of hypertension. Drugs, 2004. 64(17): p. 1923-40. [3]. Roca-Cusachs, A. and F. Triposkiadis, Antihypertensive effect of manidipine. Drugs, 2005. 65 Suppl 2: p. 11-9.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

References

[1]. Cheer, S.M. and K. McClellan, Manidipine: a review of its use in hypertension. Drugs, 2001. 61(12): p. 1777-99.

[2]. McKeage, K. and L.J. Scott, Manidipine: a review of its use in the management of hypertension. Drugs, 2004. 64(17): p. 1923-40.

[3]. Roca-Cusachs, A. and F. Triposkiadis, Antihypertensive effect of manidipine. Drugs, 2005. 65 Suppl 2: p. 11-9.

Density	1.2±0.1 g/cm3
Boiling Point	722.0±60.0 °C at 760 mmHg
Melting Point	125-128ºC
Molecular Formula	C₃₅H₃₈N₄O₆
Molecular Weight	610.699
Flash Point	390.4±32.9 °C
Exact Mass	610.279114
PSA	116.93000
LogP	5.46
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.601
Storage condition	-20°C Freezer

Hazard Codes	Xi

2-(4-benzhydryl...

CAS#:10527-64-7

UNII:5DU0E310OI

CAS#:74936-72-4

Manidipine

CAS#:89226-50-6

Literature: WO2011/23954 A2, ; Page/Page column 18 ;

3-Nitrobenzaldehyde

CAS#:99-61-6

2-(4-benzhydryl...

CAS#:89226-49-3

Methyl 3-aminoc...

CAS#:14205-39-1

~77%

Manidipine

CAS#:89226-50-6

Literature: Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797

2-(4-benzhydryl...

CAS#:10527-64-7

Manidipine

CAS#:89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797

N-Benzhydrylpip...

CAS#:841-77-0

Manidipine

CAS#:89226-50-6

Literature: WO2011/23954 A2, ;

2-(4-benzhydryl...

CAS#:89226-49-3

Manidipine

CAS#:89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797

2-(4-diphenylme...

CAS#:90120-00-6

Methyl 3-aminoc...

CAS#:14205-39-1

Manidipine

CAS#:89226-50-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3787 - 3797

Precursor 7
CAS#:10527-64-7 2-(4-benzhydryl... CAS#:74936-72-4 UNII:5DU0E310OI CAS#:99-61-6 3-Nitrobenzaldehyde CAS#:89226-49-3 2-(4-benzhydryl...
CAS#:14205-39-1 Methyl 3-aminoc... CAS#:841-77-0 N-Benzhydrylpip... CAS#:90120-00-6 2-(4-diphenylme...
DownStream 1
CAS#:89226-75-5 Manidipine hydr...

2-[4-(Diphenylmethyl)-1-piperazinyl]ethylmethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate

2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester

1-diphenylmethyl-4-(2-hydroxyethyl)piperazine

2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Manidipine 6300

Manidipine

UNII:6O4754US88

CV-4093,2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Manidipine (Manyper)

2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

(+/-)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester

2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

2-(4-benzhydryl-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Franidipine

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester

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Manidipine

Use of Manidipine

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Manidipine Biological Activity

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Precursor & DownStream

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