(E)-FeCP-oxindole

Modify Date: 2025-08-25 16:34:28

(E)-FeCP-oxindole Structure
(E)-FeCP-oxindole structure
 Common Name (E)-FeCP-oxindole
CAS Number 884338-18-5 Molecular Weight 329.17
Density N/A Boiling Point N/A
Molecular Formula C19H15FeNO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (E)-FeCP-oxindole


(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].

 Names

Name Ferrocene, [(E)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]
Synonym More Synonyms

 (E)-FeCP-oxindole Biological Activity

Description (Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].
Related Catalog
References

[1]. John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3(6):600-8.  

 Chemical & Physical Properties

Molecular Formula C19H15FeNO
Molecular Weight 329.17
Exact Mass 319.98000
PSA 29.10000
LogP 3.20130
InChIKey JGKCUURLEMXRGX-UHFFFAOYSA-N
SMILES C1CCCC1.O=C1Nc2ccccc2C1=CC1CCCC1.[Fe+2]

 Synonyms

(E)-FeCP-oxindole
SB 258719 hydrochloride
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Chemsrc provides (E)-FeCP-oxindole(CAS#:884338-18-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of (E)-FeCP-oxindole are included as well.>> amp version: (E)-FeCP-oxindole

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