1137967-28-2

1137967-28-2 structure

Name: (Z)-FeCP-oxindole
Chemical Name: (Z)-FeCP-oxindole
CAS Number: 1137967-28-2
Molecular Formula: C₁₉H₁₅FeNO
Molecular Weight: 329.173
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2021-05-02 09:10:27
Modify Date: 2025-08-27 18:07:36
(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].

Name	(Z)-FeCP-oxindole
Synonyms	Iron(2+) 2,4-cyclopentadienide 2-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-cyclopentadienide (1:1:1)

Description	(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
References	[1]. John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3(6):600-8.