884338-18-5

884338-18-5 structure

Name: (E)-FeCP-oxindole
Chemical Name: Ferrocene, [(E)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]
CAS Number: 884338-18-5
Molecular Formula: C₁₉H₁₅FeNO
Molecular Weight: 329.17
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2017-02-15 08:36:37
Modify Date: 2024-01-11 17:52:40
(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].

Name	Ferrocene, [(E)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]
Synonyms	(E)-FeCP-oxindole SB 258719 hydrochloride

Description	(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
References	[1]. John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3(6):600-8.