Clodronate disodium tetrahydrate

Modify Date: 2024-01-03 09:43:43

Clodronate disodium tetrahydrate structure	Common Name	Clodronate disodium tetrahydrate
	CAS Number	88416-50-6	Molecular Weight	360.917
	Density	N/A	Boiling Point	N/A
	Molecular Formula	CH₁₂Cl₂Na₂O₁₀P₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Clodronate disodium tetrahydrate

Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].

Name	Disodium Clodronate Tetrahydrate
Synonym	More Synonyms

Description	Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	vesicular ATP release[1]
In Vitro	Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission [1]. Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence [1]. Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis[2].
In Vivo	Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1]. Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1]. Animal Model: C57BL/6 mice (22-30 g)[1] Dosage: 10 mg/kg Administration: Intravenous injection Result: Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain.
References	[1]. Kato Y, et al. Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6297-E6305. [2]. Moriyama Y, et al. Clodronate: A Vesicular ATP Release Blocker. Trends Pharmacol Sci. 2018 Jan;39(1):13-23.