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22560-50-5

22560-50-5 structure
22560-50-5 structure
  • Name: Clodronate Disodium
  • Chemical Name: clodronic acid disodium salt
  • CAS Number: 22560-50-5
  • Molecular Formula: CH2Cl2Na2O6P2
  • Molecular Weight: 288.856
  • Catalog: Organic raw materials Organic phosphine compound
  • Create Date: 2018-03-07 08:00:00
  • Modify Date: 2025-08-22 13:31:07
  • Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases[1][2][3].
Name clodronic acid disodium salt
Synonyms Clastoban
Clodronic acid disodium salt
Cl2MDP Clodronate disodium Clodronic acid disodium salt DMDP
Bonefos
UNII-Y05R4GCQ1H
(Dichloromethylene)diphosphonic acid,disodium salt
Phosphonic acid, (dichloromethylene)bis-, sodium salt (1:2)
EINECS 245-078-9
MFCD01632786
Clasteon
Lytos
Ossiten
Sodium clodronate
disodium,[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate
Loron
Disodium Clodronate
Mebonat
Clodronate Disodium
Clodronic Acid, Disodium Salt, Hydrate
disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]
Disodium (dichloromethylene)bis[hydrogen (phosphonate)]
Ostac
Dichloromethylenediphosphonic acid disodium salt
Description Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases[1][2][3].
Related Catalog
In Vitro Clodronic acid (Clodronate) disodium salt induces rapid apoptosis in osteoclasts by preventing translocation of ADP into mitochondria after being internalised via resorption. Consequently, ATP production is inhibited, leading to induction of apoptosis by means of release of cytochrome C into the cytoplasm[2].
In Vivo Clodronic acid (Clodronate) disodium salt (6.25-25 mg/kg; p.o.; daily for 28 days) slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg[3]. Animal Model: Male Lewis rats, aged 7 weeks[3] Dosage: 6.25, 12.5, and 25 mg/kg Administration: P.o.; daily for 28 days Result: Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28.
References

[1]. Mönkkönen J, et al. Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells. Life Sci. 1994;54(14):PL229‐PL234.

[2]. Tanakol R, et al. Clodronic acid in the treatment of postmenopausal osteoporosis. Clin Drug Investig. 2007;27(6):419‐433.

[3]. Itoh F, et al. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation. 2004;28(1):15‐21.
Density 2.306g/cm3
Boiling Point 474.7ºC at 760mmHg
Melting Point >330ºC
Molecular Formula CH2Cl2Na2O6P2
Molecular Weight 288.856
Flash Point 240.9ºC
Exact Mass 287.849915
PSA 140.34000
LogP 1.30710
Vapour Pressure 2.55E-10mmHg at 25°C
Storage condition -20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ7640700
CHEMICAL NAME :
Phosphonic acid, (dichloromethylene)bis-, disodium salt
CAS REGISTRY NUMBER :
22560-50-5
LAST UPDATED :
199512
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C-H2-Cl2-O6-P2.2Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3600 mg/kg/15D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg/3D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
182 gm/kg/26W-I
TOXIC EFFECTS :
Musculoskeletal - changes in teeth and supporting structures Musculoskeletal - other changes Related to Chronic Data - death
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 59,129,1986
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS SZ7640700
HS Code 2931900090
HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
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