HIF-2α-IN-4

Modify Date: 2024-01-26 20:54:49

HIF-2α-IN-4 structure	Common Name	HIF-2α-IN-4
	CAS Number	882268-69-1	Molecular Weight	287.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉H₉N₃O₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIF-2α-IN-4

HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].

Name	HIF-2α-IN-4

Description	HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 5 μM (HIF-2α)[1]
In Vitro	HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1]. HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].
References	[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.

Molecular Formula	C₉H₉N₃O₄S₂
Molecular Weight	287.32

DC Chemicals Limited
China
Product Name: HIF-2α-IN-4
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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HIF-2α-IN-4

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