2734922-78-0
2734922-78-0 structure
- Name: HIF-2α-IN-8
- Chemical Name: HIF-2α-IN-8
- CAS Number: 2734922-78-0
- Molecular Formula: C17H11ClF7N3O
- Molecular Weight: 441.73
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
- Create Date: 2023-04-07 11:41:37
- Modify Date: 2024-04-05 15:16:10
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HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
| Name | HIF-2α-IN-8 |
|---|
| Description | HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1]. |
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| Related Catalog | |
| Target |
IC50: 9 nM (HIF2α SPA); 37 nM (HIF2α iScript); 246 nM (HIF2α HRE RGA)[1] |
| In Vivo | HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) 在小鼠体内显示出抗肿瘤活性[1]。 Animal Model: 6-9 weeks, female nude Crl:NU(NCr)-Foxn1nu-Homozygous mice (786-O mouse model)[1] Dosage: 30 mg/kg Administration: P.o.; started 34 days post tumor inoculation; daily for 21 days Result: Inhibited the tumor growth. |
| References |
| Molecular Formula | C17H11ClF7N3O |
|---|---|
| Molecular Weight | 441.73 |