HIF-2α-IN-3
Modify Date: 2025-11-05 12:09:14
HIF-2α-IN-3 structure
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Common Name | HIF-2α-IN-3 | ||
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| CAS Number | 313964-19-1 | Molecular Weight | 335.66 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H6ClN5O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIF-2α-IN-3HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1]. |
| Name | HIF-2α-IN-3 |
|---|
| Description | HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent[1]. |
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| Related Catalog | |
| Target |
IC50: 0.4 µM (HIF-2α)[1] KD: 1.1 µM (HIF-2α)[1] |
| In Vitro | HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1]. |
| References |
| Molecular Formula | C12H6ClN5O5 |
|---|---|
| Molecular Weight | 335.66 |
| Storage condition | 2-8°C |