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HIF-2α-IN-4

Names

[ CAS No. ]:
882268-69-1

[ Name ]:
HIF-2α-IN-4

Biological Activity

[Description]:

HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[Target]

IC50: 5 μM (HIF-2α)[1]


[In Vitro]

HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1]. HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].

[References]

[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H9N3O4S2

[ Molecular Weight ]:
287.32

Related Compounds