2-Nitrochlorobenzene

Modify Date: 2025-08-21 12:25:39

2-Nitrochlorobenzene structure	Common Name	2-Nitrochlorobenzene
	CAS Number	88-73-3	Molecular Weight	157.555
	Density	1.4±0.1 g/cm3	Boiling Point	245.5±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₄ClNO₂	Melting Point	31-33 °C(lit.)
	MSDS	Chinese USA	Flash Point	96.5±19.8 °C
	Symbol	GHS06	Signal Word	Danger

Name	2-Chloronitrobenzene
Synonym	More Synonyms

Density	1.4±0.1 g/cm3
Boiling Point	245.5±0.0 °C at 760 mmHg
Melting Point	31-33 °C(lit.)
Molecular Formula	C₆H₄ClNO₂
Molecular Weight	157.555
Flash Point	96.5±19.8 °C
Exact Mass	156.993057
PSA	45.82000
LogP	2.34
Vapour density	5.4 (vs air)
Vapour Pressure	0.0±0.4 mmHg at 25°C
Index of Refraction	1.580
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals.
Water Solubility	0.43 g/L (20 ºC)

2-Nitrochlorobenzene MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ0875000

CHEMICAL NAME :: Benzene, 1-chloro-2-nitro-

CAS REGISTRY NUMBER :: 88-73-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C6-H4-Cl-N-O2

MOLECULAR WEIGHT :: 157.56

WISWESSER LINE NOTATION :: WNR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 268 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/m3/6H/4W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 ppb/6H/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 ppm/6H/2W-C

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2300 ppb/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Endocrine - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 18 ppm/6H

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 4500 ppb/6H

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4011 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2897 (estimated) No. of Female Employees: 662 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301 + H311
Precautionary Statements	P280-P301 + P310-P312
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R22;R24;R52/53
Safety Phrases	S36/37/39-S45-S60-S38-S28A
RIDADR	UN 1578 6.1/PG 2
WGK Germany	2
RTECS	CZ0875000
Packaging Group	II
Hazard Class	6.1
HS Code	29049085

Precursor 10
CAS#:577-19-5 1-Bromo-2-nitro... CAS#:95-51-2 2-Chloroaniline CAS#:88-74-4 2-Nitroaniline CAS#:108-90-7 Chlorobenzene
CAS#:552-16-9 2-Nitrobenzoic acid CAS#:100-00-5 4-Chloronitrobenzene CAS#:142-04-1 Anilinium chloride CAS#:1694-92-4 o-Nitrophenylsu...
CAS#:100-66-3 Anisole CAS#:98-95-3 nitrobenzene
DownStream 9
CAS#:10468-16-3 2-chlorophenylh... CAS#:95-51-2 2-Chloroaniline CAS#:782-74-1 1,2-Bis(2-chlor... CAS#:13556-84-8 Diazene,1,2-bis...
CAS#:10565-14-7 Diethyl (2-nitr... CAS#:33265-60-0 1-(2-NITRO-PHEN... CAS#:442-52-4 clemizole CAS#:54381-13-4 Benzenamine,N-(...
CAS#:3840-18-4 2-(o-Tolyloxy)-...

HS Code	2904901100
Summary	2904901100 1-chloro-2-nitrobenzene. Supervision conditions:None.VAT:17.0% Tax rebate rate:9.0%

Dinitrochlorobenzene is inherently mutagenic in the presence of trace mutagenic contaminants.

Arch. Dermatol. 124(3) , 396-8, (1988)

2,4-Dinitrochlorobenzene (DNCB) is used for immunotherapy of alopecia areata and verruca vulgaris. We initially postulated that the presence of mutagenic contaminants in commercially available DNCB mi...

Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection.

J. Chromatogr. A. 1361 , 217-28, (2014)

Ionic liquids (ILs) were used as a new class of diluents for the analysis of two classes of genotoxic impurities (GTIs), namely, alkyl/aryl halides and nitro-aromatics, in small molecule drug substanc...

2-Chloronitrobenzene, 3-chloronitrobenzene and 4-chloronitrobenzene.

IARC Monogr. Eval. Carcinog. Risks Hum. 65 , 263-96, (1996)

2-Nitrochlorobenzene

1-Chloro-2-nitro-benzene

ortho-chloronitrobenzene

1-Nitro-2-chlorobenzene

benzene, chloronitro-

chloronitrobenzene

MFCD00007061

EINECS 201-854-9

nitrochlorobenzene

Nitrochlorobenzene, o-

o-chloronitrobenzene

o-Nitrochlorobenzene

Benzene, 1-chloro-2-nitro-

2-CHLORO-1-NITROBENZENE

1-chloronitrobenzene

Nitrochlorobenzene, ortho

1-Chloro-2-nitrobenzene

2-Chloronitrobenzene

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Nitrochlorobenzene
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Nitrochlorobenzene
Price: ￥178.0/500g
Purity: 99.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Nitrochlorobenzene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-Chloronitrobenzene
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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2-Nitrochlorobenzene

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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