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88-73-3

88-73-3 structure
88-73-3 structure
Name 2-Chloronitrobenzene
Synonyms 2-Nitrochlorobenzene
1-Chloro-2-nitro-benzene
ortho-chloronitrobenzene
1-Nitro-2-chlorobenzene
benzene, chloronitro-
chloronitrobenzene
MFCD00007061
EINECS 201-854-9
nitrochlorobenzene
Nitrochlorobenzene, o-
o-chloronitrobenzene
o-Nitrochlorobenzene
Benzene, 1-chloro-2-nitro-
2-CHLORO-1-NITROBENZENE
1-chloronitrobenzene
Nitrochlorobenzene, ortho
1-Chloro-2-nitrobenzene
2-Chloronitrobenzene
Density 1.4±0.1 g/cm3
Boiling Point 245.5±0.0 °C at 760 mmHg
Melting Point 31-33 °C(lit.)
Molecular Formula C6H4ClNO2
Molecular Weight 157.555
Flash Point 96.5±19.8 °C
Exact Mass 156.993057
PSA 45.82000
LogP 2.34
Vapour density 5.4 (vs air)
Vapour Pressure 0.0±0.4 mmHg at 25°C
Index of Refraction 1.580
Stability Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, strong bases, alkali metals.
Water Solubility 0.43 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CZ0875000
CHEMICAL NAME :
Benzene, 1-chloro-2-nitro-
CAS REGISTRY NUMBER :
88-73-3
LAST UPDATED :
199712
DATA ITEMS CITED :
26
MOLECULAR FORMULA :
C6-H4-Cl-N-O2
MOLECULAR WEIGHT :
157.56
WISWESSER LINE NOTATION :
WNR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
268 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/m3/6H/4W-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4500 ppb/6H/13W-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 ppm/6H/2W-C
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2300 ppb/6H/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Endocrine - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
18 ppm/6H
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
4500 ppb/6H
SEX/DURATION :
male 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5(Suppl 1),3,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,263,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4011 No. of Facilities: 42 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 2897 (estimated) No. of Female Employees: 662 (estimated)
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301 + H311
Precautionary Statements P280-P301 + P310-P312
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R22;R24;R52/53
Safety Phrases S36/37/39-S45-S60-S38-S28A
RIDADR UN 1578 6.1/PG 2
WGK Germany 2
RTECS CZ0875000
Packaging Group II
Hazard Class 6.1
HS Code 29049085
HS Code 2904901100
Summary 2904901100 1-chloro-2-nitrobenzene. Supervision conditions:None.VAT:17.0% Tax rebate rate:9.0%

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title: CAS No. 88-73-3 | Chemsrc address: https://www.chemsrc.com/en/baike/1027275.html

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