WRW4 TFA
Modify Date: 2025-08-29 16:08:48
WRW4 TFA structure
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Common Name | WRW4 TFA | ||
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| CAS Number | 878557-55-2 | Molecular Weight | 1104.27000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C61H65N15O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of WRW4 TFAWRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1]. |
| Name | L-Tryptophanamide, L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl |
|---|---|
| Synonym | More Synonyms |
| Description | WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1]. |
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| Related Catalog | |
| In Vitro | WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1]. |
| References |
| Molecular Formula | C61H65N15O6 |
|---|---|
| Molecular Weight | 1104.27000 |
| Exact Mass | 1103.52000 |
| PSA | 355.46000 |
| LogP | 8.65230 |
| InChIKey | IRJDOVLLPORVJP-WOAIKHIASA-N |
| SMILES | NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCCN=C(N)N)NC(=O)C(N)Cc1c[nH]c2ccccc12 |
| Storage condition | -20℃ |
| NPEC-caged-noradrenalin |