78331-26-7

78331-26-7 structure

Name: Dermorphin TFA
Chemical Name: (S)-1-(L-tyrosyl-D-alanyl-L-phenylalanylglycyl-L-tyrosyl)-N-((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate
CAS Number: 78331-26-7
Molecular Formula: C₄₂H₅₁F₃N₈O₁₂
Molecular Weight: 916.89600
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-06-13 01:48:22
Modify Date: 2024-01-09 21:16:51
Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].

Name	(S)-1-(L-tyrosyl-D-alanyl-L-phenylalanylglycyl-L-tyrosyl)-N-((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate

Description	Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	μ-opioid receptor (MOR)[1]
In Vitro	Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor[2].
References	[1]. Tiwari V, et al. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016 Mar;124(3):706-20. [2]. Bird MF, et al. Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo). PLoS One. 2016 Jun 7;11(6):e0156897.