878557-55-2

878557-55-2 structure

Name: WRW4 TFA
Chemical Name: L-Tryptophanamide, L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl
CAS Number: 878557-55-2
Molecular Formula: C₆₁H₆₅N₁₅O₆
Molecular Weight: 1104.27000
Catalog: Research Areas Neurological Disease
Create Date: 2017-06-22 13:15:40
Modify Date: 2024-01-10 09:54:24
WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].

Name	L-Tryptophanamide, L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl
Synonyms	NPEC-caged-noradrenalin

Description	WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].
References	[1]. Bae YS, et al. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol. 2004;173(1):607-614.