platencin

Modify Date: 2025-08-26 09:21:36

platencin Structure
platencin structure
Common Name platencin
CAS Number 869898-86-2 Molecular Weight 425.474
Density 1.4±0.1 g/cm3 Boiling Point 670.1±55.0 °C at 760 mmHg
Molecular Formula C24H27NO6 Melting Point N/A
MSDS N/A Flash Point 359.1±31.5 °C

 Use of platencin


Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis. Platencin inhibits β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively) with IC50s of 1.95 and 3.91 μg/ml, respectively[1].

 Names

Name Platencin
Synonym More Synonyms

 platencin Biological Activity

Description Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis. Platencin inhibits β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively) with IC50s of 1.95 and 3.91 μg/ml, respectively[1].
Related Catalog
References

[1]. Wang J, et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 670.1±55.0 °C at 760 mmHg
Molecular Formula C24H27NO6
Molecular Weight 425.474
Flash Point 359.1±31.5 °C
Exact Mass 425.183838
PSA 127.42000
LogP 4.98
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.650

 Synonyms

platencin
2,4-Dihydroxy-3-({3-[(1S,5S,6R)-5-methyl-9-methylene-4-oxotricyclo[6.2.2.0]dodec-2-en-5-yl]propanoyl}amino)benzoic acid
Benzoic acid, 3-[[3-[(4aS,8S,8aR)-1,3,4,7,8,8a-hexahydro-8-methyl-3-methylene-7-oxo-2H-2,4a-ethanonaphthalen-8-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
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