platencin

Names

[ Name ]:
platencin

[Synonym ]:
platencin
2,4-Dihydroxy-3-({3-[(1S,5S,6R)-5-methyl-9-methylene-4-oxotricyclo[6.2.2.0]dodec-2-en-5-yl]propanoyl}amino)benzoic acid
Benzoic acid, 3-[[3-[(4aS,8S,8aR)-1,3,4,7,8,8a-hexahydro-8-methyl-3-methylene-7-oxo-2H-2,4a-ethanonaphthalen-8-yl]-1-oxopropyl]amino]-2,4-dihydroxy-

Biological Activity

[Description]:

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis. Platencin inhibits β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively) with IC50s of 1.95 and 3.91 μg/ml, respectively[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Wang J, et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
670.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₇NO₆

[ Molecular Weight ]:
425.474

[ Flash Point ]:
359.1±31.5 °C

[ Exact Mass ]:
425.183838

[ PSA ]:
127.42000

[ LogP ]:
4.98

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.650

Related Compounds

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