Bischloroanthrabenzoxocinone

Modify Date: 2024-01-05 07:03:11

Bischloroanthrabenzoxocinone Structure
Bischloroanthrabenzoxocinone structure
Common Name Bischloroanthrabenzoxocinone
CAS Number 866022-28-8 Molecular Weight 391.24600
Density N/A Boiling Point N/A
Molecular Formula C23H12Cl2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bischloroanthrabenzoxocinone


Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis[1].

 Names

Name ctk5f7002
Synonym More Synonyms

 Bischloroanthrabenzoxocinone Biological Activity

Description Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis[1].
Related Catalog
In Vitro Bischloroanthrabenzoxocinone (0.01-333 µg/mL) 抑制脂肪酸合成,对 Staphylococcus aureus 和 Escherichia coli 的 IC50 值分别为 11.4、35.3 µg/mL[1]. Bischloroanthrabenzoxocinone (0-250 µg/mL) 显示出抗菌活性,对 Staphylococcus aureus 和 野生型 Escherichia coli 的 MIC 值分别为 0.2、>250 µg/mL [1]. Iscloroanthrabenzoxocinone 抑制磷脂合成,IC50 值为 0.21 μg/ml,它还抑制 Staphylococcus aureus 和 Escherichia coli 中的 DNA、RNA、蛋白质和细胞壁合成[1]。
References

[1]. Kodali S, et al. Determination of selectivity and efficacy of fatty acid synthesis inhibitors. J Biol Chem. 2005 Jan 14;280(2):1669-77.  

 Chemical & Physical Properties

Molecular Formula C23H12Cl2O2
Molecular Weight 391.24600
Exact Mass 390.02100
PSA 26.30000
LogP 6.92420

 Synonyms

bischloroanthrabenzoxocinone
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