866022-28-8

866022-28-8 structure

Name: Bischloroanthrabenzoxocinone
Chemical Name: ctk5f7002
CAS Number: 866022-28-8
Molecular Formula: C₂₃H₁₂Cl₂O₂
Molecular Weight: 391.24600
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-03-26 08:41:07
Modify Date: 2024-01-05 07:03:11
Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis[1].

Name	ctk5f7002
Synonyms	bischloroanthrabenzoxocinone

Description	Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Bischloroanthrabenzoxocinone (0.01-333 µg/mL) 抑制脂肪酸合成，对 Staphylococcus aureus 和 Escherichia coli 的 IC50 值分别为 11.4、35.3 µg/mL[1]. Bischloroanthrabenzoxocinone (0-250 µg/mL) 显示出抗菌活性，对 Staphylococcus aureus 和野生型 Escherichia coli 的 MIC 值分别为 0.2、>250 µg/mL [1]. Iscloroanthrabenzoxocinone 抑制磷脂合成，IC50 值为 0.21 μg/ml，它还抑制 Staphylococcus aureus 和 Escherichia coli 中的 DNA、RNA、蛋白质和细胞壁合成[1]。
References	[1]. Kodali S, et al. Determination of selectivity and efficacy of fatty acid synthesis inhibitors. J Biol Chem. 2005 Jan 14;280(2):1669-77.