Bischloroanthrabenzoxocinone

Names

[ Name ]:
Bischloroanthrabenzoxocinone

[Synonym ]:
bischloroanthrabenzoxocinone

Biological Activity

[Description]:

Bischloroanthrabenzoxocinone is a potent Type II fatty acid synthesis (FASII) inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Bischloroanthrabenzoxocinone (0.01-333 µg/mL) 抑制脂肪酸合成，对 Staphylococcus aureus 和 Escherichia coli 的 IC50 值分别为 11.4、35.3 µg/mL[1]. Bischloroanthrabenzoxocinone (0-250 µg/mL) 显示出抗菌活性，对 Staphylococcus aureus 和野生型 Escherichia coli 的 MIC 值分别为 0.2、>250 µg/mL [1]. Iscloroanthrabenzoxocinone 抑制磷脂合成，IC50 值为 0.21 μg/ml，它还抑制 Staphylococcus aureus 和 Escherichia coli 中的 DNA、RNA、蛋白质和细胞壁合成[1]。

[References]

[1]. Kodali S, et al. Determination of selectivity and efficacy of fatty acid synthesis inhibitors. J Biol Chem. 2005 Jan 14;280(2):1669-77.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₂Cl₂O₂

[ Molecular Weight ]:
391.24600

[ Exact Mass ]:
390.02100

[ PSA ]:
26.30000

[ LogP ]:
6.92420

Related Compounds

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