DRV1 (GPR32) agonist C2A
Modify Date: 2025-08-24 15:48:45
DRV1 (GPR32) agonist C2A structure
|
Common Name | DRV1 (GPR32) agonist C2A | ||
|---|---|---|---|---|
| CAS Number | 862811-76-5 | Molecular Weight | 364.348 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H14F2N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DRV1 (GPR32) agonist C2ADRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli. |
| Name | 3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively; elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages; also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli. |
|---|---|
| References | References 1. Chiang N, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H14F2N4O |
| Molecular Weight | 364.348 |
| Exact Mass | 364.113556 |
| LogP | 3.72 |
| Index of Refraction | 1.654 |
| InChIKey | YOVZCQZBMAXLPR-UHFFFAOYSA-N |
| SMILES | Cc1c(-c2cccc(NC(=O)c3ccc(F)c(F)c3)c2)nc2ncccn12 |
| Benzamide, 3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]- |
| 3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide |