2772379-97-0
2772379-97-0 structure
- Name: CB1/2 agonist 2
- Chemical Name: CB1/2 agonist 2
- CAS Number: 2772379-97-0
- Molecular Formula: C26H43NO3
- Molecular Weight: 417.62
- Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
- Create Date: 2022-08-31 14:57:37
- Modify Date: 2023-01-16 13:32:15
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CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity[1].
| Name | CB1/2 agonist 2 |
|---|
| Description | CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity[1]. |
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| Related Catalog | |
| Target |
hCB2-R:1.2 nM (Ki) hCB1-R:3.5 nM (Ki) |
| In Vitro | CB1/2 agonist 2 (compound 23) (1 µM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells[1]. CB1/2 agonist 2 (0-10 µM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC50 of 397.90 nM and a mean Emax value of -17.81%[1]. Cell Cytotoxicity Assay[1] Cell Line: Human hepatoblastoma (Hep-G2) cells Concentration: 1 µM Incubation Time: 24, 48 or 72 h Result: Exhibited a very low cytotoxic potential, as Hep-G2 cell viability was comparable to controls after 24-72 h of treatment. |
| In Vivo | CB1/2 agonist 2 (compound 23) (0-6 mg/kg, IP, once) significantly reduces the late phase of formalin-induced nocifensive behaviour at 6 mg/kg[1]. Animal Model: Male CD-1 outbred mice (40-45 g)[1] Dosage: 0, 1, 3, and 6 mg/kg Administration: IP, once, 10 min before the formalin or saline injection Result: Significantly reduced the late phase of formalin-induced nocifensive behaviour at the highest dose (6 mg/kg, i.p.), whereas no effect was produced by doses of 1 and 3 mg/kg. |
| References |
| Molecular Formula | C26H43NO3 |
|---|---|
| Molecular Weight | 417.62 |