TDP1 Inhibitor-2 structure
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Common Name | TDP1 Inhibitor-2 | ||
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CAS Number | 859142-95-3 | Molecular Weight | 465.28 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C25H14Cl2O5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of TDP1 Inhibitor-2TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1]. |
Name | TDP1 Inhibitor-2 |
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Description | TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1]. |
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Related Catalog | |
Target |
IC50: 0.099 ± 0.044 μM (TDP1), 3.5 ± 2.3 μM (SCAN1)[1] |
In Vitro | TDP1 Inhibitor-2 (compound 5) shows potent anti-TDP1 activity, low cytotoxicity and synergism with topotecan, an established Top1 anticancer agent[1]. |
References |
Molecular Formula | C25H14Cl2O5 |
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Molecular Weight | 465.28 |