TDP1 Inhibitor-2
Modify Date: 2025-09-10 09:41:03
TDP1 Inhibitor-2 structure
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Common Name | TDP1 Inhibitor-2 | ||
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| CAS Number | 859142-95-3 | Molecular Weight | 465.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H14Cl2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TDP1 Inhibitor-2TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1]. |
| Name | TDP1 Inhibitor-2 |
|---|
| Description | TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1]. |
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| Related Catalog | |
| Target |
IC50: 0.099 ± 0.044 μM (TDP1), 3.5 ± 2.3 μM (SCAN1)[1] |
| In Vitro | TDP1 Inhibitor-2 (compound 5) shows potent anti-TDP1 activity, low cytotoxicity and synergism with topotecan, an established Top1 anticancer agent[1]. |
| References |
| Molecular Formula | C25H14Cl2O5 |
|---|---|
| Molecular Weight | 465.28 |