K252C

Modify Date: 2024-01-11 12:32:37

K252C structure	Common Name	K252C
	CAS Number	85753-43-1	Molecular Weight	311.33700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₃N₃O	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of K252C

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].

Name	K-252c,6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Synonym	More Synonyms

Description	K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 2.45 µM (PKC)[1].
References	[1]. Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39(22), 4471-4477 (1996). [2]. Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30(3), 270-274 (2007). [3]. Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48(1), 49-60 (2000). [4]. McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003).

Molecular Formula	C₂₀H₁₃N₃O
Molecular Weight	311.33700
Exact Mass	311.10600
PSA	60.68000
LogP	4.52780

Safety Phrases	22-24/25
WGK Germany	3
HS Code	2933990090

Precursor 3
CAS#:118458-54-1 Arcyriaflavin A CAS#:51925-58-7 4-diazonio-3-ox... CAS#:40899-99-8 1H,1'H-2,2'-Biindole
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

staurosporine aglycon

Staurosporinone,K-252c

Staurosporinone

K-252C

STAUROSPORINE AGLYCONE

DC Chemicals Limited
China
Product Name: staurosporine aglycone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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