(R)-(-)-Rolipram

Modify Date: 2025-08-21 10:51:30

(R)-(-)-Rolipram structure	Common Name	(R)-(-)-Rolipram
	CAS Number	85416-75-7	Molecular Weight	275.343
	Density	1.2±0.1 g/cm3	Boiling Point	472.7±45.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₁NO₃	Melting Point	134 °C
	MSDS	N/A	Flash Point	239.7±28.7 °C

Use of (R)-(-)-Rolipram

(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Name	(4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Synonym	More Synonyms

Description	(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
In Vitro	The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner[1].
References	[1]. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.

Density	1.2±0.1 g/cm3
Boiling Point	472.7±45.0 °C at 760 mmHg
Melting Point	134 °C
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.343
Flash Point	239.7±28.7 °C
Exact Mass	275.152130
PSA	47.56000
LogP	1.43
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.552

HS Code	2933790090

Precursor 5
CAS#:67387-76-2 3-(Cyclopentylo... CAS#:621-59-0 Isovanillin CAS#:1021867-92-4 methyl 3-(3-cyc... CAS#:137-43-9 Bromocyclopentane
CAS#:162544-53-8 (E)-3-(3-(cyclo...
DownStream 0

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

(-)-rolipram

(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

(R)-(-)-Rolipram

R-(-)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)-

(R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-

(S)-ROLIPRAM

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (R)-(-)-Rolipram
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: (R)-(-)-Rolipram
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

(R)-(-)-Rolipram suppliers

Price: ￥390/1mg

Reference only. check more (R)-(-)-Rolipram price