85416-75-7

85416-75-7 structure

Name: (R)-(-)-Rolipram
Chemical Name: (4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
CAS Number: 85416-75-7
Molecular Formula: C₁₆H₂₁NO₃
Molecular Weight: 275.343
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-09-27 18:48:44
Modify Date: 2024-01-21 10:28:13
(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Name	(4R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Synonyms	(-)-rolipram (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (R)-(-)-Rolipram R-(-)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)- (R)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- (S)-ROLIPRAM

Description	(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
In Vitro	The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner[1].
References	[1]. Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.

HS Code	2933790090

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%