Lignoceric Acid-d3

Modify Date: 2024-04-05 20:09:03

Lignoceric Acid-d3 Structure
Lignoceric Acid-d3 structure
Common Name Lignoceric Acid-d3
CAS Number 851073-55-7 Molecular Weight 371.655
Density 0.9±0.1 g/cm3 Boiling Point 405.9±8.0 °C at 760 mmHg
Molecular Formula C24H45D3O2 Melting Point N/A
MSDS N/A Flash Point 182.2±13.3 °C

 Use of Lignoceric Acid-d3


Lignoceric acid-d3 is the deuterium labeled Lignoceric acid[1]. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[2][3].

 Names

Name Lignoceric Acid-d3
Synonym More Synonyms

 Lignoceric Acid-d3 Biological Activity

Description Lignoceric acid-d3 is the deuterium labeled Lignoceric acid[1]. Lignoceric acid (Tetracosanoic acid) is a 24-carbon saturated (24:0) fatty acid, which is synthesized in the developing brain. Lignoceric acid is also a by-product of lignin production. Lignoceric acid can be used for Zellweger cerebro‐hepato‐renal syndrome and adrenoleukodystrophy research[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Anna Petroni, et al. Thermogenic flux induced by lignoceric acid in peroxisomes isolated from HepG2 cells and from X-adrenoleukodystrophy and control fibroblasts. J Cell Physiol. 2019 Aug;234(10):18344-18348.  

[3]. J M Bourre, et al. Lignoceric acid biosynthesis in the developing brain. Activities of mitochondrial acetyl-CoA-dependent synthesis and microsomal malonyl-CoA chain-elongating system in relation to myelination. Comparison between normal mouse and dysmyelinating mutants (quaking and jimpy). Eur J Biochem. 1977 Jan 372(1):41-7.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 405.9±8.0 °C at 760 mmHg
Molecular Formula C24H45D3O2
Molecular Weight 371.655
Flash Point 182.2±13.3 °C
Exact Mass 371.384247
LogP 11.40
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.460

 Synonyms

Lignoceric Acid-d3
(24,24,24-2H3)Tetracosanoic acid
Tetracosanoic-24,24,24-d3 acid