HS-243
Modify Date: 2023-01-15 12:29:52
HS-243 structure
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Common Name | HS-243 | ||
|---|---|---|---|---|
| CAS Number | 848249-10-5 | Molecular Weight | 324.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H16N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HS-243HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).HS-243 binds in the ATP-binding pocket of IRAK-4.HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines. |
| Name | HS-243 |
|---|
| Description | HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).HS-243 binds in the ATP-binding pocket of IRAK-4.HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines. |
|---|---|
| References | 1. Scarneo SA, et al. J Biol Chem. 2020 Feb 7;295(6):1565-1574. |
| Molecular Formula | C17H16N4O3 |
|---|---|
| Molecular Weight | 324.34 |
| Storage condition | -20°C |