HS-10296 hydrochloride

Modify Date: 2024-01-06 20:56:22

HS-10296 hydrochloride Structure
HS-10296 hydrochloride structure
Common Name HS-10296 hydrochloride
CAS Number 2134096-03-8 Molecular Weight 562.11
Density N/A Boiling Point N/A
Molecular Formula C30H36ClN7O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HS-10296 hydrochloride


HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

 Names

Name HS-10296 hydrochloride

 HS-10296 hydrochloride Biological Activity

Description HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
Related Catalog
Target

EGFR[1].

In Vitro HS-10296 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2].
References

[1]. Sullivan I, et al. Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. Front Med (Lausanne). 2017 Jan 18;3:76.

[2]. Wu SG, et al. Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 2018 Feb 19;17(1):38.

 Chemical & Physical Properties

Molecular Formula C30H36ClN7O2
Molecular Weight 562.11
Storage condition 2-8℃
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Price: ¥6802/10 mM * 1 mL in DMSO

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