HS-10296
Modify Date: 2024-01-09 21:21:34
HS-10296 structure
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Common Name | HS-10296 | ||
|---|---|---|---|---|
| CAS Number | 1899921-05-1 | Molecular Weight | 562.11 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H36ClN7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HS-10296HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. |
| Name | HS-10296 |
|---|
| Description | HS-10296 is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. |
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| In Vitro | An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, HS-10296 binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. |
| Molecular Formula | C30H36ClN7O2 |
|---|---|
| Molecular Weight | 562.11 |
| Storage condition | -20℃ |