HS-72
Modify Date: 2025-08-27 14:13:12
HS-72 structure
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Common Name | HS-72 | ||
|---|---|---|---|---|
| CAS Number | 1800285-51-1 | Molecular Weight | 364.44 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H24N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HS-72HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity. |
| Name | HS-72 |
|---|
| Description | HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity. |
|---|---|
| References | References 1. Howe MK, et al. Chem Biol. 2014 Dec 18;21(12):1648-59. 2. Howe MK, et al. Antiviral Res. 2016 Jun;130:81-92. View Related Products by Target Heat Shock Protein (HSP) |
| Molecular Formula | C20H24N6O |
|---|---|
| Molecular Weight | 364.44 |