848249-10-5
848249-10-5 structure
- Name: HS-243
- Chemical Name: HS-243
- CAS Number: 848249-10-5
- Molecular Formula: C17H16N4O3
- Molecular Weight: 324.34
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2022-07-19 10:52:06
- Modify Date: 2023-01-15 12:29:52
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HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).HS-243 binds in the ATP-binding pocket of IRAK-4.HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines.
| Name | HS-243 |
|---|
| Description | HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).HS-243 binds in the ATP-binding pocket of IRAK-4.HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines. |
|---|---|
| References | 1. Scarneo SA, et al. J Biol Chem. 2020 Feb 7;295(6):1565-1574. |
| Molecular Formula | C17H16N4O3 |
|---|---|
| Molecular Weight | 324.34 |
| Storage condition | -20°C |