BF 227
Modify Date: 2025-08-26 15:00:43
BF 227 structure
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Common Name | BF 227 | ||
|---|---|---|---|---|
| CAS Number | 845647-80-5 | Molecular Weight | 333.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H16FN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BF 227BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils. |
| Name | BF 227 |
|---|
| Description | BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils. |
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| Related Catalog | |
| Target |
Ki: 4.3 nM (Aβ1-42)[1]. |
| In Vitro | BF-227 has a high binding affinity for Aβ1-42 fibrils. The Ki value for Aβ1-42 fibrils in competitive binding assay using [125I]BF-180 is 4.3±1.3 nM in BF-227 (Kd value of [125I]BF-180: 10.8±1.5 nM)[1]. [11C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD[2]. |
| References |
| Molecular Formula | C16H16FN3O2S |
|---|---|
| Molecular Weight | 333.38 |