H-7

Modify Date: 2025-08-26 19:35:54

H-7 structure	Common Name	H-7
	CAS Number	84477-87-2	Molecular Weight	291.36900
	Density	1.277 g/cm3	Boiling Point	495.3ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₇N₃O₂S	Melting Point	114 °C
	MSDS	Chinese USA	Flash Point	253.3ºC

Use of H-7

Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].

Name	1-(5-isoquinolinesulfonyl)-2-methylpiperazine
Synonym	More Synonyms

Description	Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKC:6 μM (Ki)
References	[1]. Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41.

Density	1.277 g/cm3
Boiling Point	495.3ºC at 760 mmHg
Melting Point	114 °C
Molecular Formula	C₁₄H₁₇N₃O₂S
Molecular Weight	291.36900
Flash Point	253.3ºC
Exact Mass	291.10400
PSA	70.68000
LogP	2.56470
Index of Refraction	1.652
Storage condition	2-8°C

H-7 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL9305000

CHEMICAL NAME :: Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-

CAS REGISTRY NUMBER :: 84477-87-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H17-N3-O2-S

MOLECULAR WEIGHT :: 291.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 30A,525,1994

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TL9305000
HS Code	2935009090

1-benzyloxycarb...

CAS#:84477-86-1

H-7

CAS#:84477-87-2

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773

2-Methylpiperazine

CAS#:109-07-9

H-7

CAS#:84477-87-2

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773

Benzyl (2S)-2-m...

CAS#:84477-85-0

H-7

CAS#:84477-87-2

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773

Precursor 3
CAS#:84477-86-1 1-benzyloxycarb... CAS#:109-07-9 2-Methylpiperazine CAS#:84477-85-0 Benzyl (2S)-2-m...
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking.

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The potassium channel Kv7.1 plays critical physiological roles in both heart and epithelial tissues. In heart, Kv7.1 and the accessory subunit KCNE1 forms the slowly activating delayed-rectifier potas...

Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease.

J. Neuropathol. Exp. Neurol. 73(8) , 770-9, (2014)

Chronic degeneration of nigrostriatal projections, followed by nigral dopaminergic cell death, is a key feature of Parkinson disease (PD). This study examines the neuroprotective potential of the rho ...

Co-receptors are dispensable for tethering receptor-mediated phagocytosis of apoptotic cells.

Cell Death Dis. 6 , e1772, (2015)

During efferocytosis, phagocytic cells recognize dying cells by receptors binding to ligands specifically exposed on apoptotic cells. Multiple phagocytic receptors and some of their signaling pathways...

H-7 dihydrochloride,(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazinedihydrochloride

H-7

H-72HCl

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: H-7
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: H-7 inhibitor
Price: $850.0/100mg $1500.0/250mg $2750.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.