Top Suppliers:I want be here
Related CAS#:
84477-87-2 84477-73-6
108930-17-2 607-09-0
152286-30-1 140663-38-3
141543-62-6 131467-86-2
97165-42-9 123237-86-5
1807096-41-8 1805322-97-7
1807082-23-0 1805368-39-1
1806932-85-3 1806829-37-7
1806029-15-1 1805083-05-9
1806758-84-8 1806821-61-3

84477-87-2

84477-87-2 structure
84477-87-2 structure
  • Name: H-7
  • Chemical Name: 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
  • CAS Number: 84477-87-2
  • Molecular Formula: C14H17N3O2S
  • Molecular Weight: 291.36900
  • Create Date: 2018-10-06 10:23:20
  • Modify Date: 2025-08-26 19:35:54
  • Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].
Name 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
Synonyms H-7 dihydrochloride,(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazinedihydrochloride
H-7
H-72HCl
Description Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].
Related Catalog
Target

PKC:6 μM (Ki)

References

[1]. Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41.

Density 1.277 g/cm3
Boiling Point 495.3ºC at 760 mmHg
Melting Point 114 °C
Molecular Formula C14H17N3O2S
Molecular Weight 291.36900
Flash Point 253.3ºC
Exact Mass 291.10400
PSA 70.68000
LogP 2.56470
Index of Refraction 1.652
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL9305000
CHEMICAL NAME :
Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-
CAS REGISTRY NUMBER :
84477-87-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H17-N3-O2-S
MOLECULAR WEIGHT :
291.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 30A,525,1994
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TL9305000
HS Code 2935009090
84477-86-1 structure

84477-86-1

~%

84477-87-2 structure

84477-87-2

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
109-07-9 structure

109-07-9

~%

84477-87-2 structure

84477-87-2

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
84477-85-0 structure

84477-85-0

~%

84477-87-2 structure

84477-87-2

Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
Precursor  3

DownStream  0

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:84477-87-2 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 84477-87-2 | Chemsrc address: https://www.chemsrc.com/en/baike/754218.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved