Ataprost
Modify Date: 2025-08-25 19:47:15
Ataprost structure
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Common Name | Ataprost | ||
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| CAS Number | 83997-19-7 | Molecular Weight | 348.47600 | |
| Density | 1.255g/cm3 | Boiling Point | 529.8ºC at 760 mmHg | |
| Molecular Formula | C21H32O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 288.3ºC | |
Use of AtaprostAtaprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm[1]. |
| Name | (5E)-5-[(3aS,4R,5R,6aS)-4-[(E,3S)-3-cyclopentyl-3-hydroxyprop-1-enyl]-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid |
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| Synonym | More Synonyms |
| Description | Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm[1]. |
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| Related Catalog | |
| Target |
Platelet aggregation[1] |
| In Vitro | Ataprost 抑制人类和狒狒富血小板血浆 (PRP) 中的血小板聚集，ED50 分别为 1.91 ng/mL 和 4.38 ng/mL[1]。 |
| In Vivo | Ataprost (50-200 μg/kg; p.o.; 单剂量) 通过口服的方式，抑制狒狒血小板聚集的 ED50 为 87 μg/kg[1]。 Ataprost (i.v.; 单剂量) 通过静脉注射的方式，抑制狒狒血小板聚集的 ED50 为 3.2 μg/kg[1]。 |
| References |
| Density | 1.255g/cm3 |
|---|---|
| Boiling Point | 529.8ºC at 760 mmHg |
| Molecular Formula | C21H32O4 |
| Molecular Weight | 348.47600 |
| Flash Point | 288.3ºC |
| Exact Mass | 348.23000 |
| PSA | 77.76000 |
| LogP | 3.68200 |
| Index of Refraction | 1.649 |
| InChIKey | DKLGLHQHLFISGJ-YLBFUXKPSA-N |
| SMILES | O=C(O)CCCC=C1CC2CC(O)C(C=CC(O)C3CCCC3)C2C1 |
| Ataprost |
| Ataprost [INN] |
| Pentanoic acid,5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-,(3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha)) |
| Ataprostum [INN-Latin] |
| Ataprostum |