Ataprost

Names

[ Name ]:
Ataprost

[Synonym ]:
Ataprost
Ataprost [INN]
Pentanoic acid,5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-,(3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha))
Ataprostum [INN-Latin]
Ataprostum

Biological Activity

[Description]:

Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[Target]

Platelet aggregation[1]

[In Vitro]

Ataprost 抑制人类和狒狒富血小板血浆 (PRP) 中的血小板聚集，ED50 分别为 1.91 ng/mL 和 4.38 ng/mL[1]。

[In Vivo]

Ataprost (50-200 μg/kg; p.o.; 单剂量) 通过口服的方式，抑制狒狒血小板聚集的 ED50 为 87 μg/kg[1]。 Ataprost (i.v.; 单剂量) 通过静脉注射的方式，抑制狒狒血小板聚集的 ED50 为 3.2 μg/kg[1]。

[References]

[1]. Adaikan PG, et al. Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates. Prostaglandins Leukot Med. 1982 Sep;9(3):307-20.

Chemical & Physical Properties

[ Density]:
1.255g/cm3

[ Boiling Point ]:
529.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₂O₄

[ Molecular Weight ]:
348.47600

[ Flash Point ]:
288.3ºC

[ Exact Mass ]:
348.23000

[ PSA ]:
77.76000

[ LogP ]:
3.68200

[ Index of Refraction ]:
1.649

Synthetic Route

Click to get detail synthetic route

Related Compounds

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