83997-19-7

83997-19-7 structure

Name: Ataprost
Chemical Name: (5E)-5-[(3aS,4R,5R,6aS)-4-[(E,3S)-3-cyclopentyl-3-hydroxyprop-1-enyl]-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
CAS Number: 83997-19-7
Molecular Formula: C₂₁H₃₂O₄
Molecular Weight: 348.47600
Catalog: Research Areas Cardiovascular Disease
Create Date: 2016-06-19 13:20:30
Modify Date: 2024-01-22 00:19:43
Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm[1].

Name	(5E)-5-[(3aS,4R,5R,6aS)-4-[(E,3S)-3-cyclopentyl-3-hydroxyprop-1-enyl]-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid
Synonyms	Ataprost Ataprost [INN] Pentanoic acid,5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-,(3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha)) Ataprostum [INN-Latin] Ataprostum

Description	Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	Platelet aggregation[1]
In Vitro	Ataprost 抑制人类和狒狒富血小板血浆 (PRP) 中的血小板聚集，ED50 分别为 1.91 ng/mL 和 4.38 ng/mL[1]。
In Vivo	Ataprost (50-200 μg/kg; p.o.; 单剂量) 通过口服的方式，抑制狒狒血小板聚集的 ED50 为 87 μg/kg[1]。 Ataprost (i.v.; 单剂量) 通过静脉注射的方式，抑制狒狒血小板聚集的 ED50 为 3.2 μg/kg[1]。
References	[1]. Adaikan PG, et al. Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates. Prostaglandins Leukot Med. 1982 Sep;9(3):307-20.