Quinacrine Dihydrochloride Dihydrate

Modify Date: 2025-08-21 15:46:46

Quinacrine Dihydrochloride Dihydrate structure	Common Name	Quinacrine Dihydrochloride Dihydrate
	CAS Number	83-89-6	Molecular Weight	399.96
	Density	1.156 g/cm3	Boiling Point	557.1ºC at 760 mmHg
	Molecular Formula	C₂₃H₃₀ClN₃O	Melting Point	247-250ºC
	MSDS	N/A	Flash Point	290.7ºC

Use of Quinacrine Dihydrochloride Dihydrate

Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)[1][2][3][4][7].

Name	quinacrine
Synonym	More Synonyms

Description	Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)[1][2][3][4][7].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Research Areas >> Infection Research Areas >> Neurological Disease
In Vitro	Quinacrine 抑制人和兔醛氧化酶，IC50 分别为 3.3 μM 和 10 μM[2]。 Quinacrine 阻断电压依赖性钠通道 (IC50: 3.3 μM)[3]。 Quinacrine (100 μM) 也是一种 PLA2 抑制剂[4]。 Quinacrine (0-20 μM, 24 h) 抑制 SGC-7901 细胞的生长，并诱导细胞凋亡[7]。 Cell Viability AssayQuinacrine 抑制人和兔醛氧化酶，IC50 分别为 3.3 μM 和 10 μM[2]。 Cell Line: SGC-7901 cell Concentration: 0, 5, 10, 15, 20 μM Incubation Time: 24 h Result: Inhibited cell growth with an IC50 value of 16.18 μM.
In Vivo	Quinacrine (3-30 mg/kg，i.p.，每日一次，连续三天) 对甘油诱导的大鼠急性肾损伤具有保护作用[5]。 Quinacrine (2.5-10 mg/kg，i.p.，每天一次，连续八周) 对环孢菌素引起的大鼠肾毒性具有保护作用[6]。 Animal Model: Acute kidney injury rat model[5] Dosage: 3-30 mg/kg Administration: i.p. Result: Attenuated glycerol induced structural and functional changes in kidney.
References	[1]. Vogtherr M, et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem. 2003 Aug 14;46(17):3563-4. [2]. Pryde DC, et al. Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53(24):8441-60. [3]. McNeal ET, et al. [3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. J Med Chem. 1985 Mar;28(3):381-8. [4]. Caro AA,et al. Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem. 2003 Sep 5;278(36):33866-77. [5]. Al Asmari AK, et al. Protective effect of quinacrine against glycerol-induced acute kidney injury in rats. BMC Nephrol. 2017 Jan 28;18(1):41. [6]. al Khader A, et al. Quinacrine attenuates cyclosporine-induced nephrotoxicity in rats. Transplantation. 1996 Aug 27;62(4):427-35. [7]. Wu X, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.

Density	1.156 g/cm3
Boiling Point	557.1ºC at 760 mmHg
Melting Point	247-250ºC
Molecular Formula	C₂₃H₃₀ClN₃O
Molecular Weight	399.96
Flash Point	290.7ºC
Exact Mass	399.20800
PSA	37.39000
LogP	6.04540
InChIKey	GPKJTRJOBQGKQK-UHFFFAOYSA-N
SMILES	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7700000

CHEMICAL NAME :: Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2- methoxy-

CAS REGISTRY NUMBER :: 83-89-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C23-H30-Cl-N3-O

MOLECULAR WEIGHT :: 400.01

WISWESSER LINE NOTATION :: T C666 BNJ EG IMY1&3N2&2 LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 239 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 714 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 13600 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 8,113,1974 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38

Quinacrine Dihydrochloride Dihydrate

2-methoxy-6-chloro-9-(1-methyl-4-diethylaminobutylamino)-acridine

2-methoxy-6-(trifluoromethyl)nicotinic acid

2-METHOXY-6-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID

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Quinacrine Dihydrochloride Dihydrate

Use of Quinacrine Dihydrochloride Dihydrate

Names

Quinacrine Dihydrochloride Dihydrate Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.