2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)-

Modify Date: 2024-01-10 09:50:59

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- Structure
2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- structure
 Common Name 2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)-
CAS Number 82855-64-9 Molecular Weight 271.27
Density 1.56g/cm3 Boiling Point 494.1ºC at 760mmHg
Molecular Formula C11H17N3O5 Melting Point N/A
MSDS N/A Flash Point 252.6ºC

 Use of 2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)-


N4,N4-Dimethylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

 Names

Name 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(dimethylamino)pyrimidin-2-one

  Biological Activity

Description N4,N4-Dimethylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Related Catalog
References

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

 Chemical & Physical Properties

Density 1.56g/cm3
Boiling Point 494.1ºC at 760mmHg
Molecular Formula C11H17N3O5
Molecular Weight 271.27
Flash Point 252.6ºC
Exact Mass 271.11700
PSA 108.05000
Index of Refraction 1.656

 Synthetic Route

2,2'-Cyclouridine structure

2,2'-Cyclouridine

CAS#:3736-77-4

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2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- Structure

2(1H)-Pyrimidin...

CAS#:82855-64-9
Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
1-β-D-Arabinofuranosyluracil structure

1-β-D-Arabinofu...

CAS#:3083-77-0

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2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- Structure

2(1H)-Pyrimidin...

CAS#:82855-64-9
Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
4-(1,2,4-triazol-1-yl)-1-(2',3',5'-tri-O-acetyl-β-D-arabinofuranosyl)pyrimidine-2(1H)one structure

4-(1,2,4-triazo...

CAS#:82855-62-7

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- Structure

2(1H)-Pyrimidin...

CAS#:82855-64-9
Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
Uridine structure

Uridine

CAS#:58-96-8

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- Structure

2(1H)-Pyrimidin...

CAS#:82855-64-9
Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
2,4(1H,3H)-Pyrimidinedione,1-(2,3,5-tri-O-acetyl-b-D-arabinofuranosyl)- structure

2,4(1H,3H)-Pyri...

CAS#:14057-18-2

~%

2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- Structure

2(1H)-Pyrimidin...

CAS#:82855-64-9
Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(4-(dimethylamino)-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate structure

(2R,3R,4R,5R)-2...

CAS#:98222-28-7

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2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)- Structure

2(1H)-Pyrimidin...

CAS#:82855-64-9
Literature: Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176
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