2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)-

Names

[ Name ]:
2(1H)-Pyrimidinone, 1-b-D-arabinofuranosyl-4-(dimethylamino)-

Biological Activity

[Description]:

N4,N4-Dimethylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

Chemical & Physical Properties

[ Density]:
1.56g/cm3

[ Boiling Point ]:
494.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₇N₃O₅

[ Molecular Weight ]:
271.27

[ Flash Point ]:
252.6ºC

[ Exact Mass ]:
271.11700

[ PSA ]:
108.05000

[ Index of Refraction ]:
1.656

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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