19-hydroxy-8(17),13-labdadien-16,15-olide
19-hydroxy-8(17),13-labdadien-16,15-olide structure
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Common Name | 19-hydroxy-8(17),13-labdadien-16,15-olide | ||
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| CAS Number | 82209-74-3 | Molecular Weight | 318.45000 | |
| Density | 1.09 | Boiling Point | N/A | |
| Molecular Formula | C20H30O3 | Melting Point | 106-107ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of 19-hydroxy-8(17),13-labdadien-16,15-olideAndrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties[1][2]. |
| Name | 4-[2-[(1R,4aS,5R,8aS)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one |
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| Synonym | More Synonyms |
| Description | Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties[1][2]. |
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| Related Catalog | |
| In Vitro | Andrograpanin exhibits anti-inflammatory properties in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways[1]. Andrograpanin enhances chemokine SDF-1α-induced leukocytes chemotaxis in Jurkat, THP-1 and PBL cells[2]. |
| References |
| Density | 1.09 |
|---|---|
| Melting Point | 106-107ºC |
| Molecular Formula | C20H30O3 |
| Molecular Weight | 318.45000 |
| Exact Mass | 318.21900 |
| PSA | 46.53000 |
| LogP | 4.02100 |
| InChIKey | WKKBRRFSRMDTJB-JYBIWHBTSA-N |
| SMILES | C=C1CCC2C(C)(CO)CCCC2(C)C1CCC1=CCOC1=O |
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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19-hydroxy-8(17... CAS#:82209-74-3 |
| Literature: Fujita, Tetsuro; Fujitani, Ryujiro; Takeda, Yoshio; Takaishi, Yoshihisa; Yamada, Toshihide; et al Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2117 - 2125 |
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Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways.
Int. Immunopharmacol. 8(7) , 951-8, (2008) Andrographis paniculata Nees is an official herbal medicine for treatment of infection and inflammation in China. Andrograpanin, the one of diterpene lactones in A. paniculata, is a hydrolysate from n... |
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Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis.
J. Cell. Biochem. 95(5) , 970-8, (2005) Andrographis paniculata is a traditional Chinese medicine (TCM) that has been effectively used for treatment of infection, inflammation, cold, fever, and diarrhea in China. However, mechanism of its t... |
| 2(5H)-Furanone,3-(2-((1R,4aS,5R,8aS)-decahydro-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl) |
| UNII-89M92UDM18 |
| 3,14-Dideoxyandrographolide |
| 19-hydroxy-8(17),13-ent-labdadien-15->16 lactone |
| andrograpanin |