2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-

Modify Date: 2024-01-11 17:30:52

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure
2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- structure
Common Name 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-
CAS Number 81691-06-7 Molecular Weight 258.23
Density 1.576g/cm3 Boiling Point N/A
Molecular Formula C10H14N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-


3-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 3-methylpseudouridine

  Biological Activity

Description 3-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.576g/cm3
Molecular Formula C10H14N2O6
Molecular Weight 258.23
Exact Mass 258.08500
PSA 124.78000
Index of Refraction 1.618

 Synthetic Route

~87%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Matsuda; Pankiewicz; Marcus; Watanabe; Fox Carbohydrate research, 1982 , vol. 100, p. 297 - 302

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Matsuda; Pankiewicz; Marcus; Watanabe; Fox Carbohydrate research, 1982 , vol. 100, p. 297 - 302
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