Esmolol hydrochloride structure
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Common Name | Esmolol hydrochloride | ||
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CAS Number | 81161-17-3 | Molecular Weight | 331.835 | |
Density | 1.026 | Boiling Point | 430.2ºC at 760 mmHg | |
Molecular Formula | C16H26ClNO4 | Melting Point | 48-50ºC | |
MSDS | USA | Flash Point | 214ºC | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Esmolol hydrochlorideEsmolol Hydrochloride is a beta adrenergic receptor blocker.Target: Adrenergic receptorEsmolol Hydrochloride is the hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation. |
Name | esmolol hydrochloride |
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Synonym | More Synonyms |
Description | Esmolol Hydrochloride is a beta adrenergic receptor blocker.Target: Adrenergic receptorEsmolol Hydrochloride is the hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation. |
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Related Catalog |
Density | 1.026 |
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Boiling Point | 430.2ºC at 760 mmHg |
Melting Point | 48-50ºC |
Molecular Formula | C16H26ClNO4 |
Molecular Weight | 331.835 |
Flash Point | 214ºC |
Exact Mass | 331.155029 |
PSA | 67.79000 |
LogP | 2.72280 |
Storage condition | −20°C |
Water Solubility | Slightly soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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~53% Esmolol hydroch... CAS#:81161-17-3 |
Literature: Yang, David J.; Oh, Chang-Sok; Kohanim, Saady; Yu, Dong-Fang; Mendez, Richard; Kim, E. Edmund Patent: US2009/238756 A1, 2009 ; Location in patent: Page/Page column 12-13 ; |
~% Esmolol hydroch... CAS#:81161-17-3 |
Literature: Synthetic Communications, , vol. 42, # 5 p. 722 - 726 |
~% Esmolol hydroch... CAS#:81161-17-3 |
Literature: Synthetic Communications, , vol. 42, # 5 p. 722 - 726 |
HS Code | 2922199090 |
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Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Esmolol: immunomodulator in pyelonephritis by Pseudomonas aeruginosa.
J. Surg. Res. 198 , 175-84, (2015) Based on previous animal studies showing promising immunomodulatory efficacy esmolol, a selective β1-blocker, it was assumed that administration of esmolol in experimental pyelonephritis by multidrug-... |
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Effect of Retroperitoneal Lavage with Normal Saline Containing Adrenaline on Carbon Dioxide Absorption in Patients Undergoing Retroperitoneal Laparoscopic Surgery.
J Laparoendosc Adv Surg Tech A 25 , 903-7, (2015) To determine the effect of lavage with adrenaline solution on CO2 absorption during retroperitoneal laparoscopic surgery.Sixty patients scheduled to undergo retroperitoneal laparoscopic surgery were d... |
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