Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Esmolol hydrochloride
Price: ￥848.0/5g ￥278.0/1g
Purity: 99.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Esmolol Hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Esmolol hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: esmolol hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

81161-17-3

81161-17-3 structure

Name: Esmolol hydrochloride
Chemical Name: esmolol hydrochloride
CAS Number: 81161-17-3
Molecular Formula: C₁₆H₂₆ClNO₄
Molecular Weight: 331.835
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-02 16:22:26
Esmolol Hydrochloride is a beta adrenergic receptor blocker.Target: Adrenergic receptorEsmolol Hydrochloride is the hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.

Name	esmolol hydrochloride
Synonyms	esmolol hcl Benzenepropanoic acid, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, methyl ester, hydrochloride (1:1) Esmolol Hydrochloride EsmololHclC16H25No4Hcl 3-(4-{2-hydroxy-3-[(1-méthyléthyl)amino]propoxy}phényl)propanoate de méthyle chlorhydrate Methyl-3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoathydrochlorid methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate hydrochloride (1:1) benzenepropanoic acid, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-, methyl ester, hydrochloride MFCD00941432 methyl 3-(4-{2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl)propanoate hydrochloride Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate hydrochloride UNII:V05260LC8D Methyl 3-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}propanoate hydrochloride (1:1) Methyl 3-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}propanoate hydrochloride Brevibloc Methyl-3-(4-{2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl)propanoathydrochlorid EsMolol Hcl API

Description	Esmolol Hydrochloride is a beta adrenergic receptor blocker.Target: Adrenergic receptorEsmolol Hydrochloride is the hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Cardiovascular Disease

Density	1.026
Boiling Point	430.2ºC at 760 mmHg
Melting Point	48-50ºC
Molecular Formula	C₁₆H₂₆ClNO₄
Molecular Weight	331.835
Flash Point	214ºC
Exact Mass	331.155029
PSA	67.79000
LogP	2.72280
Storage condition	−20°C
Water Solubility	Slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DA8346000

CHEMICAL NAME :: Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride

CAS REGISTRY NUMBER :: 81161-17-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H25-N-O4.Cl-H

MOLECULAR WEIGHT :: 331.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 775 ug/kg/14M-C

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,484,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 560 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: NCDREP New Cardiovascular Drugs. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) 1985- Volume(issue)/page/year: 3,99,1985

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R52/53
Safety Phrases	61
RIDADR	NONH for all modes of transport
WGK Germany	-
RTECS	DA8346000
HS Code	2922199090

81147-94-6

75-31-0

~53%

81161-17-3

Literature: Yang, David J.; Oh, Chang-Sok; Kohanim, Saady; Yu, Dong-Fang; Mendez, Richard; Kim, E. Edmund Patent: US2009/238756 A1, 2009 ; Location in patent: Page/Page column 12-13 ;

501-97-3

81161-17-3

Literature: Synthetic Communications, , vol. 42, # 5 p. 722 - 726

5597-50-2

81161-17-3

Literature: Synthetic Communications, , vol. 42, # 5 p. 722 - 726

Precursor 4
81147-94-6 75-31-0 501-97-3 5597-50-2
DownStream 1
81148-15-4

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

81161-17-3	861161-17-3
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103598-03-4	56-99-5
132937-89-4	6138-79-0