D,L-erythro-PDMP hydrochloride

Modify Date: 2025-08-26 16:38:33

D,L-erythro-PDMP hydrochloride Structure
D,L-erythro-PDMP hydrochloride structure
Common Name D,L-erythro-PDMP hydrochloride
CAS Number 80943-40-4 Molecular Weight 427.02
Density N/A Boiling Point N/A
Molecular Formula C23H39ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of D,L-erythro-PDMP hydrochloride


D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].

 Names

Name D,L-erythro-PDMP hydrochloride

 D,L-erythro-PDMP hydrochloride Biological Activity

Description D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].
Related Catalog
In Vitro D,L-erythro-PDMP hydrochloride (0, 12, 25, 50 μM; 0, 4, 7, 10 d)显示出对兔皮肤成纤维细胞生长的抑制作用[1]。 D,L-erythro PDMP hydrochloride (50 μM; 3 d)对兔皮肤成纤维细胞的细胞形态具有细胞毒性[1]。 D,L-erythro-PDMP hydrochloride(40 μM;24 h;MDCK 细胞)诱导葡萄糖基转移酶比活性显着增加:14.6 nmol/h 每毫克蛋白质[2]。 D,L-erythro-PDMP hydrochloride (40 μM; 6 h)保护细胞免受暴露于环己酰亚胺的细胞中合酶的损失[2]。
References

[1]. Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108(4):525-30.  

[2]. Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.  

 Chemical & Physical Properties

Molecular Formula C23H39ClN2O3
Molecular Weight 427.02
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