D,L-erythro-PDMP hydrochloride

Names

[ CAS No. ]:
80943-40-4

[ Name ]:
D,L-erythro-PDMP hydrochloride

Biological Activity

[Description]:

D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

D,L-erythro-PDMP hydrochloride (0, 12, 25, 50 μM; 0, 4, 7, 10 d)显示出对兔皮肤成纤维细胞生长的抑制作用[1]。 D,L-erythro PDMP hydrochloride (50 μM; 3 d)对兔皮肤成纤维细胞的细胞形态具有细胞毒性[1]。 D,L-erythro-PDMP hydrochloride（40 μM；24 h；MDCK 细胞）诱导葡萄糖基转移酶比活性显着增加：14.6 nmol/h 每毫克蛋白质[2]。 D,L-erythro-PDMP hydrochloride (40 μM; 6 h)保护细胞免受暴露于环己酰亚胺的细胞中合酶的损失[2]。

[References]

[1]. Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108(4):525-30.  

[2]. Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H39ClN2O3

[ Molecular Weight ]:
427.02

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.