80943-40-4

80943-40-4 structure

Name: D,L-erythro-PDMP hydrochloride
Chemical Name: D,L-erythro-PDMP hydrochloride
CAS Number: 80943-40-4
Molecular Formula: C₂₃H₃₉ClN₂O₃
Molecular Weight: 427.02
Catalog: Research Areas Others
Create Date: 2023-06-18 17:34:00
Modify Date: 2025-08-26 16:38:33
D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].

Name	D,L-erythro-PDMP hydrochloride

Description	D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	D,L-erythro-PDMP hydrochloride (0, 12, 25, 50 μM; 0, 4, 7, 10 d)显示出对兔皮肤成纤维细胞生长的抑制作用[1]。 D,L-erythro PDMP hydrochloride (50 μM; 3 d)对兔皮肤成纤维细胞的细胞形态具有细胞毒性[1]。 D,L-erythro-PDMP hydrochloride（40 μM；24 h；MDCK 细胞）诱导葡萄糖基转移酶比活性显着增加：14.6 nmol/h 每毫克蛋白质[2]。 D,L-erythro-PDMP hydrochloride (40 μM; 6 h)保护细胞免受暴露于环己酰亚胺的细胞中合酶的损失[2]。
References	[1]. Uemura K, et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. J Biochem. 1990 Oct;108(4):525-30. [2]. Abe A, et al. Induction of glucosylceramide synthase by synthase inhibitors and ceramide. Biochim Biophys Acta. 1996 Feb 16;1299(3):333-41.

Molecular Formula	C₂₃H₃₉ClN₂O₃
Molecular Weight	427.02