Balsalazide

Modify Date: 2025-08-23 17:59:32

Balsalazide Structure
Balsalazide structure
 Common Name Balsalazide
CAS Number 80573-04-2 Molecular Weight 357.318
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C17H15N3O6 Melting Point 254-255ºC
MSDS N/A Flash Point N/A

 Use of Balsalazide


Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

 Names

Name balsalazide
Synonym More Synonyms

 Balsalazide Biological Activity

Description Balsalazide could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
Related Catalog
Target

STAT3

IL-6

In Vivo At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].
Animal Admin Mice[1] C57B/L6J mice are randomly divided into four groups: CAC group, Balsalazide (BSZ) group (300 mg/kg), VSL#3 group, and BSZ+VSL#3 group. After two weeks, the AOM/DSS model is induced by AOM injection followed by two cycles of 2% DSS[1].
References

[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61.

[2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 254-255ºC
Molecular Formula C17H15N3O6
Molecular Weight 357.318
Exact Mass 357.096100
PSA 148.65000
LogP 1.00
Index of Refraction 1.650
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG4974900
CHEMICAL NAME :
Benzoic acid, 5-((4-(((2-carboxyethyl)amino)carbonyl)phenyl)azo)-2- hydroxy-, (E)-
CAS REGISTRY NUMBER :
80573-04-2
LAST UPDATED :
199406
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C17-H15-N3-O6
MOLECULAR WEIGHT :
357.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,313,1984
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,313,1984

 Safety Information

Risk Phrases R20/21/22
Safety Phrases S36/37

 Synonyms

BALSALAZIDE SODIUM
balsalazido
(3E)-3-({4-[(2-Carboxyethyl)carbamoyl]phenyl}hydrazono)-6-oxo-1,4-cyclohexadiene-1-carboxylic acid
Balsalazide
BALSALAZIDE DISODIUM SALT
1,4-Cyclohexadiene-1-carboxylic acid, 3-[2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]hydrazinylidene]-6-oxo-, (3E)-
BALSALZIDE DISODIUM
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