Balsalazide disodium

Modify Date: 2025-08-25 21:41:25

Balsalazide disodium Structure
Balsalazide disodium structure
Common Name Balsalazide disodium
CAS Number 150399-21-6 Molecular Weight 437.312
Density N/A Boiling Point N/A
Molecular Formula C17H17N3Na2O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Balsalazide disodium


Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

 Names

Name Balsalazide disodium
Synonym More Synonyms

 Balsalazide disodium Biological Activity

Description Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
Related Catalog
Target

STAT3

IL-6

In Vivo At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].
References

[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61.

[2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

 Chemical & Physical Properties

Molecular Formula C17H17N3Na2O8
Molecular Weight 437.312
Exact Mass 437.081116
PSA 172.77000
LogP 0.30320

 Safety Information

RIDADR UN 2222 3 / PGIII
HS Code 2853009090

 Customs

HS Code 2853009090

 Synonyms

Balsalazide Disodium Salt Dihydrate
Balsalzide Disodium Hydrate
5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic Acid Disodium Salt Dihydrate
sodium, μ-[5-[(E)-2-[4-[[[2-(carboxy-κO)ethyl]amino]carbonyl]phenyl]diazenyl]-2-hydroxybenzoato(2-)-κO]-, hydrate (1:2)
Balsalazide disodium
Sodium 5-[(E)-{4-[(2-carboxylatoethyl)carbamoyl]phenyl}diazenyl]-2-hydroxybenzoate hydrate (2:1:2)
Benzoic acid, 5-[(E)-2-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]diazenyl]-2-hydroxy-, sodium salt, hydrate (1:2:2)
Balsalazide (sodium hydrate)
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